Executive Committee

President

Olivier HERAULT, MD, PhD

Professor of hematology

Tours university hospital, Tours

INSERM UMR1069

INSERM UMS61

OPALE Carnot Institute

olivier.herault@univ-tours.fr

Ravalet N et al. Modulation of bone marrow and peripheral blood cytokine levels by age and clonal hematopoiesis in healthy individuals. Clin Immunol 2023, 255:109730.
Roux B et al. Aberrant DNA methylation impacts HOX genes expression in bone marrow mesenchymal stromal cells of myelodysplastic syndromes and de novo acute myeloid leukemia. Cancer Gene Ther 2022, 29:1263
Mancini SJC et al. Deciphering tumor niches: lessons from solid and hematological malignancies. Front Immunol 2021, 12:766275
Vignon C et al. Involvement of GPx-3 in the reciprocal control of redox metabolism in the leukemic niche. Int J Mol Sci 2020, 21:8584
Kouzi F et al. Disruption of gap junctions attenuates acute myeloid leukemia chemoresistance induced by bone marrow mesenchymal stromal cells. Oncogene 2019, 39:1198

Vice President

Fatima MECHTA-GRIGORIOU, PhD

Research Director INSERM

Institut Curie, Paris

INSERM U1339 / CNRS UMR3666

fatima.mechta-grigoriou@curie.fr

https://curie.fr/equipe/mechta-grigoriou

Croizer H*, Mhaidly R*, et al. Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer. Nat Commun 2024, 15:2806
Licaj M*, Mhaidly R*, et al. Residual ANTXR1+ myofibroblasts after chemotherapy inhibit anti-tumor immunity via YAP1 signaling pathway. Nat Commun 2024, 15:1312
Cohen C, et al. WNT-dependent interaction between inflammatory fibroblasts and FOLR2+ macrophages promotes fibrosis in chronic kidney disease. Nat Commun 2024, 15:743
Peltier A*, Seban RD* et al. Fibroblast heterogeneity in solid tumors: From single cell analysis to whole-body imaging. Semin Cancer Biol 2022, 86:262
Kieffer Y, et al. Single cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer. Cancer Discov 2020, 10:1330

Vice President

Véronique MAGUER-SATTA, PhD

Research Director CNRS

Cancer Research Center of Lyon, Lyon

CNRS UMR5286 / INSERM U1052

veronique.maguer-satta@cnrs.fr

https://www.crcl.fr/en/citi-department/bmp-ecosystem-stemness-and-dynamic-in-cancer/

Zylbersztejn F et al. Human myeloid differentiation by BMP4 signaling through the VDR pathway in acute myeloid leukemia. Cell Death Discov 2024, 10:325
Guyot B et al. An early neoplasia index (ENI10), based on molecular identity of CD10 cells and associated stemness biomarkers, is a predictor of patient outcome in many cancers. Cancer Res Com 2023, 3:1966
Voeltzel T, et al. A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes. Biomat Sci 2022, 10:485
Prunet A, et al. A new agarose-based microsystem to investigate cell response to prolonged confinement. Lab Chip 2020, 20:4016
Risson E et al. The current paradigm and challenges ahead for the dormancy of disseminated tumor cells. Nat Cancer 2020, 1:672

Secretary

Nathalie MAZURE, PhD

Research Director CNRS

Mediterranean Center for Molecular Medicine , Nice

INSERM U1065

mazure@univ-cotedazur.fr

Fabbri L et al. Identification of a new aggressive axis driven by ciliogenesis and absence of VDAC1-ΔC in clear cell renal cell carcinoma patients. Theranostics 2020, 10:2696
Meyenberg Cunha-de Padua M et al. Evidences of a rirect relationship between cellular fuel supply and ciliogenesis regulated by hypoxic VDAC1-ΔC. Cancers (Basel) 2020, 12:3484
Bai H et al. Artery to vein configuration of arteriovenous fistula improves hemodynamics to increase maturation and patency. Sci Transl Med 2020, 12:eaax7613
Fabbri L et al. Primary cilium in cancer hallmarks. Int J Mol Sci 2019, 20:1336
Brahimi-Horn MC et al. Local mitochondrial-endolysosomal microfusion cleaves the voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol 2015, 35: 1491

Deputy Secretary

Karl BALABANIAN, PhD

Research Director INSERM

Saint Louis Research Institute, Paris

INSERM U1160

Université Paris Cité

karl.balabanian@inserm.fr

https://www.balabanian-espeli-lab.com/

Debureaux PE et al. Inflammatory Waldenström Macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort. Blood 2025, 145:450
Rondeau V et al. CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism. Sci Signal 2024, 17:eadl5100
Anginot A et al. WHIM Syndrome-linked CXCR4 mutations drive osteoporosis. Nat Commun 2023, 14:2058
Boy M et al. Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation. Nat Commun 2023, 14:588
Alouche N et al. Hematological disorder associated Cxcr4-gain-of-function mutation leads to uncontrolled extrafollicular immune response. Blood 2021, 137:3050

Treasurer

Stéphane MANCINI, PhD

Research Director INSERM

INSERM U1236 MOBIDIC, Rennes

stephane.mancini@univ-rennes1.fr

https://mobidic.univ-rennes1.fr/project-4-bone-marrow-supportive-niches-b-all

Touarin P et al. Pre-B cell receptor acts as a selectivity switch for galectin-1 at the pre-B cell surface. Cell Rep 2024, 43:114541
Rondeau V et al. CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism. Sci Signal 2024, 17:eadl5100
Fregona V et al. Stem cell-like reprogramming is required for leukemia-initiating activity in B-ALL. J Exp Med 2024, 221:e20230279
Pelletier J et al. Niche-expressed Galectin-1 is involved in pre-B acute lymphoblastic leukemia relapse through pre-B cell receptor activation. iScience 2023, 26:106385
Delahaye MC et al. Toward Therapeutic Targeting of Bone Marrow Leukemic Niche Protective Signals in B-Cell Acute Lymphoblastic Leukemia. Front Oncol 2021, 10:606540

Deputy Treasurer

Gwendal LAZENNEC, PhD

Research Director CNRS

CNRS UMR9005 SYS2DIAG, Montpellier

gwendal.lazennec@sys2diag.cnrs.fr

http://gwendal.lazennec.free.fr/

Lazennec G et al. CXCR2 chemokine receptor – a master regulator in cancer and physiology. Trends Mol Med 2024, 1: 37
Anginot A et al. WHIM Syndrome-linked CXCR4 mutations drive osteoporosis. Nat Com 2023, 14:2058
Delobel P et al. CXCR2 intrinsically drives the maturation and function of neutrophils in mice. Front Immunol 2022, 13: 1005551
Timaxian C et al. Pivotal role for Cxcr2 in regulating tumor-associated neutrophil in breast cancer. Cancers (Basel) 2021, 13:2584
Boissière-Michot F et al. CXCR2 levels correlate with immune infiltration and a better prognosis of triple negative breast cancers. Cancers (Basel) 2021, 13: 2328

Councillor

Marie-Caroline Le BOUSSE-KERDILES, PhD

Research Director INSERM

INSERM UMRS-MD1197, Villejuif

caroline.le-bousse-kerdiles@inserm.fr

Guarrigue A et al. Human Oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome. J Clin Invest 2025, Jan 23:e180981
Voeltzel T, et al. A minimal standardized human bone marrow microphysiological system to assess resident cell behavior during normal and pathological processes. Biomat Sci 2022, 10:485
Tseng HW et al. Spinal cord injury reprograms muscle fibroadipogenic progenitors to form heterotopic bones within muscles. Bone Res 2022, 10:22
Mancini SJC et al. Deciphering tumor niches: lessons from solid and hematological malignancies. Front Immunol 2021, 12:76627
Vignon C et al. Involvement of GPx-3 in the reciprocal control of redox metabolism in the leukemic niche. Int J Mol Sci 2020, 21:E8584

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